Folder keeps opening upon startup ..

The folder “D:\Program Files\Microsoft” keeps opening every single time on my computer. It’s gotten really annoying, and I want it to stop. I’ve looked all over the internet, but I’ve never found any definite solutions. Please help. Thanks.
Answer #1
Check if the item is in Start–>Programs–>Startup. If so, open it and remove the entry.
Answer #2
Easy way to get around it is to rename the folder…Just add a number at the end…Restart and rename back…