Prototype PC Game crashes
August 5th, 2016
Could be lots of issues. If I remember right with Prototype, you need to re-install PhysX Config. to fix the crashes. Try turning your game resolution down and AA to off or 2x also may help.
Check this mate: All about the havoc encountered while playing this game and the solutions.
http://forums.steampowered.com/forums/showthread.php?t=903444